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IgM antibodies are the first immunoglobulin isotype to appear. for yellow fever, Japanese encephalitis, tick-borne encephalitis), the patients develop a primary antibody response characterized by a slow increase of specific antibodies.

When dengue infection occurs in persons who have not previously been infected with a flavivirus or immunized with a flavivirus vaccine (e.g. At the end of the acute phase of infection, serology is the method of choice for diagnosis.Īntibody response to infection differs according to the immune status of the host ( 1). During the early stages of the disease, virus isolation, nucleic acid or antigen detection can be used to diagnose the infection. After the onset of illness, the virus can be detected in serum, plasma, circulating blood cells and other tissues for 4–5 days. Laboratory diagnosis methods for confirming dengue virus infection may involve detection of the virus, viral nucleic acid, antigens or antibodies, or a combination of these techniques. early detection of severe cases, case confirmation and differential diagnosis with other infectious diseases), surveillance activities, outbreak control, pathogenesis, academic research, vaccine development, and clinical trials. Efficient and accurate diagnosis of dengue is of primary importance for clinical care (i.e.

Instal the new for mac Starus Word Recovery 4.6